Mehdi Alrubayee


Dundee Dental School

Park Place



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Project Title: Development of an alternative alveolar bone graft for cleft lip and palate

PhD Supervisors: Professor Peter Mossey & Dr Sarah Jones

Cleft lip and palate or Orofacial clefts (OFCs) are among the most common congenital malformations with an average of 1.7 per 1000 live births (Mossey, et al., 2009). They are immediately recognizable disruptions of normal facial structures (Dixon, et al., 2011). Children born with OFCs have difficulty in feeding and need multidisciplinary care from birth to adulthood, including surgery, speech therapy, general dentistry and orthodontics (Mossey et al., 2009). Untreated craniofacial defects may give rise to many untoward sequelae. Deficiency of bone support for teeth adjacent to cleft, unfavourable oral hygiene conditions leading to caries and periodontal disease, mobile maxillary segments with unfavourable prosthetic condition for future prosthesis, speech impairment resulting from a narrow arch or residual fistulas, and communication between oral and nasal cavities with nasal crusting. Bone graft harvested from the iliac crest is the gold standard for palate repair. However, donor site morbidity is the main accompanying problem. Tricalcium Phosphate is the promising alternative material for autologous bone graft. The main aim of this project is to test Tricalcium phosphate granules supplied by Xpand company/ Holland as an alternative synthetic material by testing the osteoinductivity, osteoconductivity and osteodegradibility in vitro.