Professor Mark P Hector

Head of Department and Dean of Dentistry

Address:

Dundee Dental School
Park Place
Dundee
DD1 4HN

GDC No. 56126

Phone Number:

+44 (0)1382381 661

Email Address:

m.p.hector@dundee.ac.uk

Mark Hector was born in Nairobi, Kenya and first graduated in Physiology, then in Dentistry in 1981 from Guys Hospital. There followed 3 years at the University of Bristol and Kings College, London after which he received his PhD. Following 3 years in oral medicine and pathology at Guys Hospital Dental School he was recruited to The London Hospital Medical College as a lecturer in Child Dental Health. He gained his Readership in 2001 and in 2002 became Professor of Oral Health of Children at Barts and The London School of Medicine and Dentistry. Between 2009-11 he was President of the International Association of Paediatric Dentistry.

Mark Hector took up his position as Dean of Dentistry and Professor of Oral Health of Children at Dundee University in August 2011.

To maintain a degree of sanity he is a silversmith.

My research to date has been based on the physiological control of salivary secretion and the role of saliva in the maintenance of the healthy mouth in children and adults. The range of research projects I am now involved with reflects by broad interest and knowledge of oral biology and its applications to clinical problems encountered in both paediatric and adult dentistry. I have successfully supervised 3 post doc RAs, 11 PhD students, and co-supervising 3 others.

My breadth of knowledge in a wide range of topics and my research experience is reflected by regularly being asked to examine doctoral theses (17 to date). I have much experience in supervising taught postgraduate student research projects, with over 30 students presenting their work at international meetings. Of the 50-plus masters students I have supervised, 10 have been awarded distinction overall and a further 6 received distinction grades for their projects. We have thrice (1995, 1997 and 2005) won the highly prestigious biennial Bengt Magnussen Memorial Prize and in 2001 the Morita Prize by the International Association of Paediatric Dentistry. In 2006 one of my students won the Young Scientist Award from the European Academy of Paediatric Dentistry. In 2010 another won the Mineralised tissue prize of EAPD.

Dental Caries, Enamel Erosion and Salivary Proteins

Mechanisms by which salivary calcium, phosphate and fluoride interact with salivary proteins on the tooth surface to both prevent demineralisation and promote remineralisation of deciduous and permanent enamel with Dr Paul Anderson and Jelena Kosoric. This latter work was made possible through grants (£123,000) to build a computer driven Scanning Micro-Radiographic facility allowing us to capture real-time effects over periods of several weeks This work resulted in both UK and European Patents to cover the use of the peptide in oral care products aimed at older patients suffering from xerostomia (mouthwash) and toothpastes for general use. We also secured funding for proof of concept studies and another 2 studentship to look at the efficacy of different amino acid sequencing on the Calcium binding and enamel protective properties of this peptide work towards the development of In vivo intra oral devices to test the efficacy of these novel peptides in prevention of erosion.

Masticatory function and food selection with implant stabilized dentures

There is a growing appreciation that elderly people have increasing difficulties in selecting foods that they can chew effectively. This becomes even more apparent when they are reliant on complete or partial dentures. Together with Prof. Paul Wright and Prof. Robin Heath and Dr.Robin.Crompton (University of Liverpool) we were awarded BBSRC funding (£375,048) for the development and validation of a numerical model of food comminution. An important follow-on project will be the role that saliva has in the handling and comminution of food prior to bolus formation in the mouth and swallowing. It has offered us an insight into the pattern of food selection by individuals who have impaired masticatory function. As part of this a PhD student successfully developed an objective in vitro and in vivo methods to measure the forces needed to bite through food and in particular to determine how changing the morphology of the prosthetic teeth influences the chewing efficiency.

Dentine hypersensitivity

Affecting over 25% of the adult population dentine hypersensitivity is a distressing condition leading to considerable reduction in quality of life. Dr Anderson and I had a funded PhD studentship with an ORS award and a CASE award from Glaxo-Smith-Kline to look at both the structure of dentine in relation to hypersensitivity and the mass transport of ions through dentine with the aim of better understanding and developing systems to manage this very common condition.

Radiographic ageing of children

With large numbers of children being involved in emigration from their homelands it is becoming apparent that the existing indices for the estimation their age are needed. It is also necessary for forensic (including mass graves) and archaeological sites where human child remains are discovered. Dr Helen Liversidge and I have conducted a number of studies to determine whether dental radiographs are an effective means to do this. This has involved population-based studies of ethnically homogenous groups (Caucasian, Bengali) and is expanding to include peoples from the middle east, African states (Somalia, central and southern) Australia/New Zealand and the Far East. This study has investigated the effects of chronic malnutrition and sickness so that we understand the effects these have on growth and development of the dentition. This has led to the publication of an Atlas of Tooth Development and Eruption.

I have extensive experience in teaching in both basic medical sciences and clinical disciplines at undergraduate and postgraduate levels. My teaching is well received, and regularly highly reviewed by our students.

Whilst at Queen Mary, University of London, I was responsible for the research, process of consultation, planning and presentation of the 1999 dental curriculum strategy, and also had responsibility to ensure that the implementation of this innovative course was managed effectively and efficiently.

I had responsibility for Dental Hygiene and Dental Therapy training and have taken a very close interest in their clinical training in paediatric dentistry, and took over responsibility for Dental Nurse Training at Barts and The London and oversaw the planning a new curriculum reflecting the (then draft) GDC outcomes-based document.

I designed and implemented the Intercalated Degree programme in Oral Biology (8 modules).

In post graduate (TPG) courses, I was responsible for writing writing and implementing the two-year full-time MClinDent in Paediatric Dentistry and a full time MSc in Oral Biology.

Anderson, D.J., Hector, M.P. and Linden, R.W.A. (1985) The possible relation between mastication and parotid secretion in the rabbit. Journal of Physiology, 364; 19-30.

Hector, M.P. (1986) The Masticatory-Salivary Reflex in 'Current Topics in Oral Biology. A Symposium. University of Bristol Press, 311-320.

Anderson, D.J. and Hector, M.P. (1987) Periodontal mechanoreceptors and parotid secretion in animals and man. Proceedings of the 10th International Conference on Oral Biology Journal of Dental Research, 66; 518-523.

Hector, M.P. and Linden, R.W.A. (1987) The possible role of periodontal mechanoreceptors in the control of parotid secretion in man. Quarterly Journal of Experimental Physiology, 72: 285-302.

Hector, M.P. and Tripathi, P. (1990) The effect of chewing side on parotid amylase secretion in conscious rabbits. Archives of Oral Biology, 35: 71-73.

Ikawa, M. Hector, M.P. and Proctor, G.B. (1991). Parotid secretion from the rabbit during feeding. Experimental Physiology, 76: 717-724.

Hector, M.P. (1991) The secretion of saliva and its' proteins. Journal of the Sendai Dental Society, 61: 5-8.

Muller,F., Heath, M.R., Kazazoglu, E. and Hector, M.P. (1992) Contribution of periodontal receptors and food qualities to masseter muscle inhibition in man. Journal of Oral Rehabilitation, 20: 281-290

Hector, M.P. and Sullivan, A. (1992) Migration of erythrosin during unilateral stimulation of saliva in man. Archives of Oral Biology, 37: 757-758.

Sullivan, A and Hector, M.P. (1995) Inconsistent levels of mutans streptococci and lactobacilli measured in stimulated whole saliva. European Journal of Oral Science, 103: 99-102.

Anderson, D.J., Hector, M.P. and Linden, R.W.A. (1996) The effects of unilateral and bilateral chewing and simulated bruxism, on the masticatory-parotid salivary reflex in man. Experimental Physiology, 81: 305-312.

Egan, C.A, Bishop, M.A., and Hector, M.P. (1996) An immunohistochemical study of the pulpal nerve supply in primary human teeth: evidence for the innervation of deciduous dentine. Journal of Anatomy, 188: 623-631.

V.Schonfeld, J., Hector, M. Evans, D.F. and Wingate, D.L. (1997) Oesophageal acid and salivary secretion: Is chewing gum a treatment option for gastro-oesophageal reflux? Digestion, 58: 111-114.

Hector, M.P. and Rogers, C.E.A. (1997) Guidelines for the taking of initial radiographs of children. International Journal of Paediatric Dentistry, 7: 191-199

Heather Fry, Mark P. Hector, Jeremy M. Hardie, Kirsten Larkin and Christopher E. Mercer (1998) Evolution of the curriculum at one London Dental School; An interim account. Journal of Dental Education, 62: 709-714.

Moriyama, Y, Hector, M.P. and Croucher, R. (1999) Knowledge and reported behaviour concerning the prevention of caries in children: a questionnaire survey of Japanese parents resident in London, UK.International Dental Journal, 49: 115-121

Egan, C.A., Hector, M.P. and Bishop, M.A. (1999) On the pulpal nerve supply to the primary human teeth: Evidence for the innervation of deciduous dentine.International Journal of Paediatric Dentistry, 9: 57-66.

Liversidge, H.M., Speechley, T. and Hector, M.P.(1999) Dental maturation in British children: are Demirjian’s standards applicable? International Journal of Paediatric Dentistry, 9:261-268

Hector M.P.and Linden, R.W.A. (1999) Reflexes of Salivation. In Frontiers of Oral Science, Karger,Ed. J.R. Garrett, L. Anderson and J. Engstrom . Germany. Pp 196-218

Carol A. Francis, Mark P. Hector and Gordon B. Proctor. (2000) Freeze-thawing of human saliva precipitates specific proteins Archives of Oral Biology, 45: 601-606.

De Aza P.N. Luklinska Z.B. Anseau, M.P. Hector, M.P. Guitan, M, and De Aza, S. (2000) Reactivity of a Wollastonite- tricalcium phosphate bioeutectic ceramic in human saliva. Biomaterials, 21:1735-1741.

Niedermeyer, W., Huber, M., Fischer, D., Beier, N., Muller, R., Schuler, R., Brinninger, A., Fartasch, M, Diepgen, Th., Matthaeus, C., Meyer, C., and Hector, M.P. (2000) Significance of saliva for the denture-wearing population. Gerodontology, 104-119

Abewumi. A, Hector, M.P. and King. J. (2001) The role children have in obtaining their informed consent for routing dental care. British Dental Journal, 191: 256-259

Anderson, P, Hector, M.P. and Rampersad, M.A (2001) Critical pH in resting and stimulated whole saliva in groups of children and adults. International Journal of Paediatric Dentistry, 11:266-273

S.M.Mc Donnell and M.P. Hector (2001) The distribution of saliva in children. International Journal of Paediatric Dentistry, 11:416-422

Carol A. Francis, Mark P. Hector and Gordon B.Proctor. (2001) Kallikrein and Pre-kallikrein in resting and stimulated human parotid and submandibular saliva. European Journal of Oral Sciences, 109: 365-368.

C.E.A.Rogers and M.P.Hector (2003) Tooth brushing and oral hygiene habits of children under 7 years living in Hertfordshire. Community Practitioner,76: 14-17

S.A.Gaubert and M.P.Hector.(2003) Mechano-sensitive responses of traumatised permanent incisor teeth in children. Dental Traumatology, 19:145-153

H.M. Liversidge, F. Lyons and M.P. Hector.(2003) The accuracy of three methods of age estimation using radiographic measurements of developing teeth. Forensic Science International, 131: 22-29

Mc Donnell, S.T. and Hector, M.P. 2003)Chewing side preferences in children. Journal of Oral Rehabilitation. 2004 Sep;31(9):855-60.

Mikami, Y., Wakai, S., Croucher, R., Hector,MP, Nakamura, Y (2003). Children’s dental health: British expatriot residents in Tokyo,Japan. International Dental Journal 53, 280-284

A. Kosmidou, H.M. Liversidge and M.P. Hector An estimation of developmental age using tooth length in children suffering from Dystrophic Epidermolysis Bullosa. International Journal of Paediatric Dentistry. (in press)

Doel, J.J., Hector, M.P., Amirthan, C., Al Anzan, L., Benjamin, N., and Allaker, R.P. (2004)

Protective effect of salivary nitritrate and microbial nitrite reductase activity against caries. European Journal of Oral Sciences ; 112: 424-428

Doel, J.J., Benjamin, N. Hector M.P., Rogers, M., and Allaker,R.P. (2005) Evaluation of bacterial nitrate reduction in the oral cavity. European Journal of Oral Sciences ; 113:1-6

Johal, AS, Hector, MP,Battagel, JM and Kotecha BT. (2005) The Impact of Mandibular Advancement Splint therapy in subjects with sleep related breathing disorders. European Journal of Orthodontics. 27:607-614

Liversidge HM, Kosmidou A, Hector MP, and Roberts GJ. (2005) Dental Developmental age in Epidermolysis Bullosa. International Journal of Paediatric Dentistry 15:335-341.

Maber,M., Liversidge, HM., Hector MP (2006) Accuracy of age estimation of radiographic methods using developing teeth. Forensic Science International. March 11 EPUB PMID 16533584

A. H. Brook, C. Underhill, L. K. Foo and M. Hector. (2006) Approximal Attrition and Permanent Tooth Crown Size in a Romano-British Population' Dental Anthropology, 19:23-28.

Boyen Huang, Wagner Marcenes, Ray Croucher, Mark Hector , (2007) Accidental and non-accidental causes of traumatic dental injuries. Dental Traumatology (in press)

Jelena Kosoric, Ralph Anthony D Williams Mark Hector and Paul Anderson (2007) A synthetic peptide based on a natural salivary protein reduces demineralisation in model systems for enamel caries and erosion. International Journal of peptide research and therapeutics. DOI 10,1007/S10989-007-9085-0 7 pages

P.Anderson, J,Kosoric and M.P.Hector (2007) The Calcium Management action of salivary proteins for caries and erosion prevention. CPD Dentistry 2007; 6: 31-37

Johal,A., Hector, M.P., Battagel, J.M. and Kotecha, B.T. (2007)

The impact of sleep nasendoscopy on the outcome of mandibular advancement splint therapy in subjects with sleep-related breathing disorders. doi: 10.1017/S0022215106003203 The Journal of Laryngology and Otology 121; 668-675

Jelena Kosoric, Ralph Anthony D Williams Mark Hector and Paul Anderson (2008) A synthetic peptide based on a natural salivary protein reduces demineralisation in model systems for enamel caries and erosion. International Journal of peptide research and therapeutics. DOI 10,1008/S10989-008-9085-0 7 pages

Santos O, Kosoric J, Lindh L, Hector MP, Anderson P Adsorption of salivary protein statherin and its subunit onto hydrophobic and hydrophilic surfaces: a model study of salivary biofilm formation using ellipsometry, J Colloid Sci Interface 2008; 318 (2), p.175-182

P.Anderson, J,Kosoric and M.P.Hector (2008) The Calcium Management action of salivary proteins for caries and erosion prevention. CPD Dentistry 2008; 6: 31-37

Xianzhong Xu, Mark Hector, Paul Wright, Robin Heath and, (2008) Force, rate and work used during incisor penetration with different textural foods. Journal of Textural Studies, 39; 115-128

M Kawabata MP Hector, GR Davis, CR Parkinson GD Rees and P Anderson 2008. Diffusion Transport within Dentinal Tubules: an X-ray microtomographic study. Archives of Oral Biology, 53: 736-743

Huang B, Marcenes W, Croucher R, Hector M. (2009) Activities related to the occurrence of traumatic dental injuries in 15- to 18-year-olds. Dental Traumatology, 25:64-8.

Boyen Huang, Wagner Marcenes, Ray Croucher, Mark Hector , (2009) Activities related to the occurrence of traumatic dental injuries in 15-to-18-year-olds Dental Traumatology (Dental Traumatology and Endodontics) 25. 64-68

Johal, J.M. Battagel, M.P. Hector (2009) Mandibular advancement splint therapy in subjects with sleep-related breathing disorders. European Respiratory Journal (in press)

Johal, A., Battagel, J.M., Hector, M.P. (2009) Controlled, prospective trial of psychosocial function before and after mandibular advancement splint therapy. American Journal of Orthodontics and Dentofacial Orthopedics (In Press).

Alquatani,SJ, HectorMP and Liversidge,HM (2010) The London Atlas of tooth development and eruption. American Journal of Physical Anthropology. 142:481-490 http://www.ncbi.nlm.nih.gov/pubmed/20310064

Shah S, Kosoric J, Hector MP, Anderson P (2012 ). An in vitro scanning microradiography study of the reduction in hydroxyapatite demineralization rate by statherin-like peptides as a function of increasing N-terminal length (EOS-5261-CA-11.R1) in press

UK Patent and EU Patent

No: P38364WO Statherin peptide and its use in medicine - P.Anderson, MPHector, J Kosoric RAD Williams

Over 200 Contributions to scientific conferences and congresses.