Dr. Sarah J Jones

Lecturer

Address:

Division of Oral and Maxillofacial Clinical Sciences
Dundee Dental Hospital and School
Park Place
Dundee DD1 4HR

Phone Number:

+44 (0)1382381 632

Email Address:

s.j.jones@dundee.ac.uk

Dr Sarah Jones graduated in from Liverpool University in 1988 with an honours degree in Biochemistry. She then studied for a PhD in the Department of Genetics and Microbiology, again at Liverpool University and was awarded her PhD in 1992.

Sarah then worked as a scientific officer at the Paterson Institute for Cancer Research in Manchester. She then moved to Scotland and completed two post-doctoral positions at St. Andrews University before arriving in Dundee in 1999. Sarah then worked as a post-doctoral research assistant until 2011 when she was promoted to the post of lecturer.

Sarah teaches the pre-clinical years of the BDS programme and also supervises final year BSc and BMSc laboratory-based research projects for basic science, dental and medical students.

Sarah is also 1BDS examination convenor and leads the standard setting process for 1BDS.

Sarah is an active member of two research groups focusing on Oral Cancer and Craniofacial Anomalies and currently supervises PhD and MRes research projects in both of these areas.

Sarah’s research interests fall into three main categories; craniofacial abnormalities, oral cancer and dental materials and she co-supervises research projects in all of these areas. The craniofacial abnormality projects are supervised in conjunction with Professor Mossey and Dr Ian Ellis and focus on palatogenesis and the team collaborates with groups in Manchester and Madrid. Sarah also attends ESF and EUROCleftNet meetings and conferences.

Sarah is currently co-supervisor of one PhD and one MDSc student working on cancer-based projects.

Current Projects:

     - Is there a Role for Activated Akt in Palatogenesis?

     - Palatogenesis: Is there a Relationship Between TGFβ3 and Hyaluronan  Synthase (Has 1, 2, 3) Expression in vitro?

 

Regarding oral cancer, Sarah’s main interests are centred on the role of angiogenesis promoters and suppressors in cancer and its progression. Sarah is currently co-supervisor of one PhD and one MDSc student working on cancer-based projects.

Current Projects:

-          Role of Signal Transduction in Oral Tumour Cell Migration

-          Synthesis of Hyaluronan by Tumour Cells – Mechanisms and Implications

Sarah is also involved in several novel multi-disciplinary PhD projects looking at dental materials.

Current Projects:

-          Approaches to Root Caries Restoration; Exploring a Bioengineering Approach to Tissue Adhesion of Glass Polyalkenote Cements.

-          Role of Matrix Metalloproteinases in the Failure of Tooth Root Canal Restorations.

UNDERGRADUATE TEACHING

Sarah is involved in teaching the first and second year BDS Microbiology practical course and also supervises final year BSc and BMSc laboratory-based research projects for basic science, dental and medical students. Sarah also gives lectures to 1BDS on the biochemistry of digestion. Sarah, in her role as 1st BDS examination convenor, holds feedback sessions and is a student mentor.

 

Examples of Undergraduate Research Projects:

-          Palatogenesis: Is there a Relationship Between TGFβ3 and Hyaluronan Synthase (Has 1, 2, 3) Expression in vitro?

 

-          Is there a Role for MTA Filling Material and Bone Morphogenetic Protein 2 (BMP2) in the Activating “resting” Stromal Cells to an Active Phenotype? 

 

-          EGF AND TGF-alpha Motogenic Activities are Mediated by the EGF Receptor: Identification of the Signalling Pathways Relevant in Oral Cancer.

 

-          Is there a Role for Activated Akt in Palatogenesis?

 

POSTGRADUATE TEACHING

Sarah currently co-supervises two PhD, two MDSc and one MSc student, and contributes towards the taught (practical) component of the MRes degrees in Cancer Biology and Oral Cancer. She also leads one of the modules in the MRes in Oral Cancer; Cell proliferation and cancer.

Islam, M.R., Jones, S.J.,  Macluskey, M. and Ellis I.R. (2014)

Is there a pAkt between VEGF and Oral Cancer Cell Migration? Cellular Signalling (accepted with corrections)

 

Islam, M.R.,  Ellis I.R., Macluskey, M., Cochrane, L. and Jones, S.J. (2014)

Phosphorylation of Akt at Threonine 308 as a prognostic factor in VEGF-positive HNSCC. (Submitted to British Journal of Cancer.)

 

Galloway, J., Jones, S.J., Mossey, P. and Ellis, I. (2013). The Control and Importance of Hyaluronan Synthase Expression in Palatogenesis. Frontiers in Physiology, 4: article 10

 

Ellis, I.R., Islam, M.R., Aljorani, L. and Jones, S.J. (2012) Fibronectin: The N-Terminal Region and Its Role in Cell Migration - Implications for Disease and Healing. In: Fibronectin: Current Concepts in Structure, Function and Pathology, ed. J.Beattie, published by Nova Publishers NY USA.

 

Schor, S.L., Ellis, I.R., Jones, S.J., Woolston A.M. and Schor, A. (2012). Bi-stable Switch in Migration Stimulating Factor (MSF) Expression is Regulated by the Concerted Signalling of TGFβ and Matrix. International Journal of Cancer. 130(9):2024-32.

 

Schor, S.L., Ellis, I.R., Jones, S.J., Woolston A.M. and Schor, A. (2012). Bi-stable Switch in Migration Stimulating Factor (MSF) Expression is Regulated by the Concerted Signalling of TGFβ and Matrix. International Journal of Cancer. 130(9):2024-32.

 

Aljorani, L. E., Bankfalvi, A., Carey, F. A., Harada, K., Ohe, G., Jones, S. J., Ellis, I. R., Schor, S. L. and Schor, A. M. (2011), Migration-stimulating factor as a novel biomarker in salivary gland tumours. Journal of Oral Pathology & Medicine. 40(10):747-54.

 

Ellis, I.R., Jones, S.J., Lindsay, Y., Schor, A.M., Schor, S.L., Leslie, N. (2010) Migration Stimulating Factor (MSF) promotes fibroblast migration by inhibiting AKT. Cellular Signalling 22, 1655-1659.

 

Ellis, I.R., Jones, S.J., Staunton, D., Vakonakis, I., Norman, D.G. , Potts, J., Schor, A.M., Schor, S.L. (2010) Multi-Factorial Modulation of IGD Motogenic Potential in MSF (Migration Stimulating Factor). Experimental Cell Research, 316 2465-2476.

 

Schor, S.L., Schor, A.M., Ellis, I.R., Jones S.J., Florence, M.M., Cox, J. and Woolston A.M.  (2009). The Oncofetal Paradigm Revisited: MSF and HA as Contextual Drivers of Cancer Progression. In: Hyaluronan In Cancer Biology. Editor Robert Stern pp 283-306.

 

Motegi, K., Harada, K., Ohe, G., Jones, S.J., Ellis, I.R., Crouch, D.H., Schor, S.L., Schor, A.M. (2008). Differential involvement of TGF-β1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells. Experimental Cell Research, 314 (13), pp. 2323-2333. 

 

Schor, A.M., Ellis, I.R., Jones, S.J., Perrier, S.,  Florence, M.M., Cox, J., Ohe, G., Kankova, K., Vojtesek, B., Thompson, A.M., Purdie, C., Kazmi, S., Foo, S., Woolston A.M. and Schor, S.L., (2008). Identification and role of migration stimulating factor isoforms in breast carcinomas. Breast Cancer Research , 10 (Suppl 2): P66doi:10.1186/bcr1950

 

Jones, S.J., Florence, M.M., Ellis, I.R., Kankova, K., Schor, S.L., Schor, A.M. (2007)
Co-expression by keratinocytes of migration stimulating factor (MSF) and a functional inhibitor of its bioactivity (MSFI). Experimental Cell Research, 313 (20), pp. 4145-4157. 

 

Jones, S.J., Ellis, I.R., Kankova, K., Thompson, A.M., Preece, P., Kazmi, S., Schor, S.L and Schor, A.M. (2006). Evaluation of migration-stimulating factor expression for breast cancer diagnosis and prognosis. Breast Cancer Research, 8 (Suppl 2) : P19doi:10.1186/bcr1574

 

 

Kay, R.A., Ellis, I.R., Jones, S.J., Perrier, S., Florence, M.M., Schor, A.M., Schor, S.L. (2005). The expression of migration stimulating factor, a potent oncofetal cytokine, is uniquely controlled by 3′-untranslated region-dependent nuclear sequestration of its precursor messenger RNA. Cancer Research, 65 (23), pp. 10742-10749.

 

Schor, S.L., Ellis, I.R., Jones, S.J., Baillie, R., Seneviratne, K., Clausen, J., Motegi, K., Vojtesek, B., Kankova, K., Furrie, E., Sales, M.J., Schor, A.M. and Kay, R.A. (2003). Migration Stimulating Factor: A genetically truncated onco-fetal fibronectin isoform expressed by carcinoma and tumour associated stromal cells. Cancer Research, 63, 8827-8836.

 

Smith, V.J., Fernandes, J.M.O., Jones S.J. and Kemp, G.D. and Tatner, M.F. (2000).

Antibacterial Proteins in Rainbow Trout, Oncorhynchus mykiss. Fish and Shellfish Immunology, 10, Iss.3 pp243-260.

 

Jones, S.J., Iqbal, M., Grierson, A.W. and Kemp, G. (1996). Activation of the protease from human adenovirus type 2 is accompanied by a conformational change that is dependent on cysteine 104. Journal of General Virology, 77, 1821-1824.

 

Jones, S.J., Molineux, G., Dexter, T.M. and Friedenstein, A.(1993).

Factor for Fibroblast Colony Forming Unit. Patent Application 94924931.2-2105

Conference Papers

Jones, S.J., Thurman, D.A. and Tomsett, A.B. (1991). Purification of a metallothionein-like peptide from the flowering plant Mimulus guttatus. In the abstract of papers presented at The 1991 Stress proteins and Heat-Shock Response Meeting, Cold Spring Harbor Laboratories, NewYork, USA.

 

Cabrita, C., Iqbal, M., Jones, S., Murray, H., Reddy, H. and Kemp, G. (1996). Mechanisms of Activation in the Adenovirus Protease.  In: Abstracts of the Xth International Congress of Virology, Jerusalem, Israel.   

                                               

Jones, S., Cabrita, C., Iqbal, M. and Kemp, G. (1997). Adenovirus Type 2 Protease - Activation and Catalysis. In: Abstracts of the Keystone symposium on Proteolysis and Protein Processing, Taos, New Mexico, USA.    

 

Schor, A., Schor, S. & ♦ Jones S.J. (2005). Evaluation of MSF Expression for breast cancer diagnosis and prognosis. Invited speaker at Breast Cancer Campaign Induction Day, London, UK. (♦ speaker).

 

Jones, S.J., Florence, M.M., Ellis, I.R., Kay, R.A.,  Cox, J., Kankova, K., Schor, S.L., Schor A.M. (2006). A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF. Poster at the British Microcirculation Society Annual Scientific Meeting and Symposium: EDHF in the microcirculation. Dundee, UK.

 

Macluskey, M.,  Jones, S., Stenhouse, S.,  McLoughlin, P., Ellis, I., H. Alkhadar, (2008). Vascularity and disease progression in head and neck squamous carcinoma.

Poster for Pan European Federation of the IADR, London, UK.

                                               

Galloway, J., Ellis, I.R., Jones, S.J., Dixon M. and Mossey, P. (2010)

Differential Expression of Hyaluronan Synthases in Palatogenesis

Poster for IADR, Barcelona, Spain.

 

Islam, M., Alkhadar, H., Paterson, Z., Macluskey, M., Jones, S.J., Mossey, P.A. & Ellis I.R. (2011). Is there a pAkt between VEGF and motility in Oral Cancer? TOR, PI3K and Akt – 20 Years On. Basel, Switzerland, f1000 poster.

 

Jones, S.J., Ellis, I.R., Woodley, N., Galloway, J., Figge, M. and Mossey, P. (2013)

Characterisation of the Role of TGFβ3 in the Control of Hyaluronan Synthesis by HAS2. Oral presentation at the EUROCleftNet Research Conference, Plovdiv, Bulgaria. (♦ speaker).